Two years after Commander Shepard repelled the invading Reapers bent on the destruction of organic life, a mysterious new enemy emerges. On the fringes of known space, something is silently abducting entire human colonies. Shepard must work with Cerberus, a ruthless organization devoted to human survival at any cost, to stop the most terrifying threat mankind has ever faced.
To even attempt this perilous mission, Shepard must assemble the galaxy's most elite team and command the most powerful ship ever built. Even so, they say it will be suicide. Commander Shepard intends to prove them wrong.