Set seven years after the episodes of Cole MacGrath activated the Ray Field Inhibitor (RFI) to destroy a Conduit (superhumans named for their ability to "channel" powers) named John White, also known as the Beast and cure the Plague. Fearing the Conduits' abilities, the Department of Unified Protection (D.U.P.), an organization formed by the US eastern seaboard and the worldwide economy, that handles any sort of bio-terrorism to ensure that the events of Empire City and New Marais don't repeat themselves. It was also revealed that the D.U.P. renamed Conduits into Bioterrorists and have been rounding them up. Using propagandized messages via news and public service, the D.U.P. forced many Conduits out of hiding by turning the general public against them, and sent them to Curdun Cay, a prison designed to contain and experiment on Conduits. It was revealed that the developers assumed the good ending of InFAMOUS 2 as canon and that, rather than the RFI destroying all Conduits, some survived the explosion. While it was originally thought to have killed all Conduits across the globe, some Conduits proved resistant to the device due to the long distance from New Marais. Rather than the fictional cities of the previous two games, InFamous: Second Son takes place in Seattle, although locations and features have been changed to allow for better gameplay flow.